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Charcot-Marie-Tooth disease

Charcot-Marie-Tooth (CMT) disease is named after the three neurologists who first noted the condition around a century ago. CMT is an inherited neurological disease, which is characterised by the slow degeneration of muscles in the lower legs, feet, hand and forearms.

There are different types of CMT, each resulting in varying symptoms and levels of severity. Type 1, usually referred to as CMT1, affects the insulating covering surrounding the nerve fibres, and symptoms are usually first noticed during late childhood or adolescence. Type 2, CMT2, affects the nerve fibres themselves and may start to become noticeable a little later in life.

CMT is sometimes called Hereditary Motor and Sensory Neuropathies (HMSN) or Peroneal Muscular Atrophy (PMA). Dejerine-Sottas Disease is also very similar to Charcot-Marie-Tooth disease and is sometimes referred as CMT3.

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