Diagnosis of Primary biliary cirrhosis

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When symptoms of primary biliary cirrhosis are presented to a doctor, the first step in diagnosis is often a blood test for a substance called AMA (Anti-mitochondrial Antibody). This antibody is a substance produced by the disease-fighting system of the body and around 95% of those with PBC will test positive for this antibody.

In the early stages of PBC the liver is smooth and enlarged. As the condition progresses, nodules (bumps) appear and the liver becomes stained with bile.

Blood tests to check liver function, and a liver biopsy (a test on a tiny sample of tissue), help to determine levels of waste substances such as copper, or bodily substances such as bilirubin. If levels were particularly high, it would point to the condition.

X-rays and ultrasound scans can also be used to determine the size of the liver and rule out other causes of symptoms.

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