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Causes of Osteoarthritis骨性关节炎的成因

The cause of osteoarthritis is unknown, but there are factors that increase the likelihood of developing the disease, such as repeated strenuous activity.事业的骨性关节炎是未知的，但也有因素，增加的可能性发展的疾病，如反复艰苦的活动。 However, the condition is commonly linked with injury or deformities of the skeleton that disturb the normal workings of the joints and the joint surfaces.不过，条件是普遍联系在一起的损伤或畸形的骨骼扰乱正常的运作，关节及联合表面。 Being overweight makes osteoarthritis significantly worse.超重，使骨性关节炎的显着恶化。

The disease process involves damage to the cartilage-covered, weight-bearing surface of the bones, and there is sometimes widening or re-modelling (changing of the shape) of the ends of the bones involved in the joint.这种疾病的过程中涉及的损害软骨覆盖，重量型轴承表面的骨头，且有，有时扩大或重新建模（改变形状）的两端的骨头所涉及的中英联合。 In spite of the name (‘-itis’ usually means ‘inflammation’), relatively little inflammation is seen.尽管该国名称（ â € 〜 -i tis†™通常意味着â € 〜 i nflammation†™ ） ，相对较少炎症被认为是。 New spurs of bone often develop at the margins of the affected joints.马刺队的新骨往往是发展的边缘受影响的关节。

Factors that contribute to osteoarthritis include:因素，有助于骨性关节炎，包括：

  • a physical injury to the joint, 1人身伤害，以联合，
  • too much pressure from high body weight (obesity),太多的压力，高体重（肥胖） ，
  • change in the physical relationship of the bone-ends caused by rickets, bow-legs, knock-knee and congenital changes of shape,变化，在身体的关系，骨两端所造成的佝偻病，弓腿，连锁膝盖和先天性的变化形状，
  • over-use of certain joints,过度使用某些关节，
  • infection,感染，
  • damage to the nerve supply to the joint, and损害神经供应联合，并
  • other joint diseases such as gout or rheumatoid arthritis.联合其他疾病，如痛风或类风湿关节炎。

There is evidence of a genetic factor in osteoarthritis.有证据表明，遗传因素在骨性关节炎。 Recent research suggests for the first time that there may be a hereditary basis for osteoarthritis.最近的研究表明，对于第一次有可能是一个遗传基础，为骨性关节炎。

This research does not suggest that there is a gene for osteoarthritis.这项研究并不意味着是有骨性关节炎的基因。 It does, however, indicate that genetic factors probably contribute to the development of the disease.然而，它表明，遗传因素可能的发展作出贡献疾病。 As in many other conditions, osteoarthritis is probably a disease in which environmental factors operate on a person who is already genetically vulnerable to developing the condition.正如在许多其他条件，骨性关节炎的可能是一种疾病，其中环境因素的运作，一个人谁是易受伤害的基因已经向发展中国家的条件。